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Recent Articles
When intellectual dishonesty becomes a crime: Nature and its cynical promotion of bad science. PDF Print E-mail
by Edward Hooper   
Monday, 01 December 2008
Early in October 2008 an article proposing a new, earlier year of origin for HIV-1, the pandemic AIDS virus, was published in Nature. For several reasons I, and scientists whom I know, considered this article a travesty, and one that spoke volumes about the conduct of Science in the 21st Century.

The principal author of the article, "Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960", was Michael Worobey, an ambitious young Canadian scientist who had recently been appointed - while still in his early thirties - to head the laboratory of Ecology and Evolutionary Biology at the University of Arizona, in Tucson.

Worobey's article dealt with huge mathematical calculations done on "super-computers". In reality, however, it was a mish-mash of arguments about the likely date of the beginnings of the AIDS pandemic, which concluded that the first example of HIV-1 must have existed in humans in or around 1908. Unfortunately, Worobey's calculations were based on a scientific model (the "phylogenetic clock", or "molecular clock") that is entirely bogus when applied to a lentiretrovirus such as HIV-1. The results he came up with are therefore equally spurious.

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More Worobey Misinformation PDF Print E-mail
by Edward Hooper   
Friday, 10 October 2008

The AIDSOrigins Webmaster has just drawn my attention to the following article on the Web. Apparently entitled: The AIDS Conspiracy Handbook, it was written by Juliet Lapidos.

It lists several wacky theories about the origins of AIDS. One of the theories that features is the OPV theory, and Ms Lapidos sums up as follows:

"Hooper's contaminated polio vaccine thesis sounds less wacky than most conspiracy theories and has attracted support from a few notable academics-including late Oxford professor W.D. Hamilton. But it's definitely wrong. Hooper says Koprowski got his kidney samples from chimps in the Congo. The problem is that the SIV strain endemic to chimps from that region is phylogenetically distinct from HIV. The offending chimps probably came from Cameroon."

But the claim that the OPV theory is definitely wrong is itself incorrect. The precise source of the chimpanzees that bore the SIV (or SIVs) that crossed into humans to make HIV-1 is still unproven. Ms Lapidos asserts that they "probably came from Cameroon", but the truth is that we still don't know. However, there is documentary evidence that at least one Pan troglodytes troglodytes (Ptt) chimpanzee from the west central African region that includes Cameroon was present among Koprowski's chimps in the Congo. (In reality, there were probably several such Ptt chimps present, but the one single documented chimp proves the point.) Because these chimps were co-caged and group-caged together, an SIV introduced by one single chimpanzee could have infected many others in the camp. For the OPV theory to work, it requires only one such SIV-infected chimp to provide kidney cells or sera that were used in the vaccine.

I was surprised at that very technical phrasing: "phylogenetically distinct from HIV" in the Lapidos article. Where had she picked up such a phrase, I wondered. But my surprise only lasted until I reached the bottom of the article, where Michael Worobey is thanked for his help. It seems that Dr Worobey is actively trying to discredit the OPV theory on the Web. Of course, one of the best ways of doing that is to try to link it to daft conspiracy theories.....and then for good measure to assert that it's "definitely wrong".

In an accompanying article, "HIV-1 in 1908?", I reveal among other things that Dr Worobey (who writes articles that seek to prove that the OPV theory is "definitely wrong") has been actively collaborating for the last seven years with the doctors who made and administered the suspect vaccine that was used in the Congo in the 1950s. These include Dr Koprowski's deputy in that era, Dr Stanley Plotkin. We may also safely assume that Dr Koprowski himself, now 91, is a "silent partner" in the enterprise. Now we see Worobey actively trying to diss the OPV theory on the Web. And he claims that he doesn't have an agenda!

Sorry, Dr Worobey, but you've been found out. Again!!

Ed Hooper. October 10th, 2008.

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HIV-1 in 1908? Another sad comedy of errors from Michael Worobey PDF Print E-mail
by Edward Hooper   
Thursday, 09 October 2008

October 9th, 2008.

As forecast in my piece "Worobey's wobbly research", first posted on this site on March 19th, 2008, the Canadian molecular biologist Michael Worobey has just published new calculations about the age of the AIDS virus, HIV-1, which place its origins even further back in time.

His work appears in the form of a lengthy letter to the journal Nature, entitled "Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960", by M. Worobey, D.E. Teuwen, M. Bunce, S.M. Wolinsky et al.; [Nature; 2008 (October 2nd); 455; 661-664.]

On the basis of this one newly-discovered sample of HIV-1 dating from 1960, Worobey and his colleagues contend that the first human infection with the AIDS virus occurred in 1908, with outer confidence limits stretching from 1884 to 1924.

The previous "best guess" of molecular biologists such as Bette Korber was that the first HIV-1 virus existed in a human being by 1931. This in itself was a highly dubious finding. But the 1908 "guestimate" by Worobey and his team from the Department of Ecology and Evolutionary Biology at the University of Arizona is now being highlighted by extensive coverage and publicity in Nature, and then spoon-fed to a largely compliant press corps.

Worobey's calculations, according to his supporters Beatrice Hahn and Paul Sharp, who have been invited by Nature to write the accompanying commentary, employ "state-of-the-art statistical analyses". But they are actually based on just the one crucial new piece of data, this being a fragment of genetic sequence allegedly obtained from the stored lymph node of an African woman in 1960. Just like the the famous 1959 sample (the oldest known sample of HIV), this 1960 sample comes from a subject who was then living in the Belgian Congo capital of Leopoldville, (now Kinshasa, Democratic Republic of Congo). This, quite clearly, is a significant detail, and yet not one of the press articles covering Worobey's paper seems to have picked it up. I, and the small group of people on whose wisdom and scientific expertise I informally rely (three quarters of whom are professional scientists, some of them quite eminent scientists) are strongly persuaded that these exciting-sounding dates from Worobey are highly dubious. We believe that his analysis and interpretation of the 1960 viral sequence are in reality little more than wishful thinking based on poorly-supported science.

We also believe that the discovery of that 1960 sample of HIV-1, and the coincidence of place with the 1959 HIV-1 sample, is the real story here, not Worobey's highly speculative 1908 guestimate of when the first AIDS virus might have existed. A much simpler and better-supported explanation for the recently- discovered 1960 HIV-1 fragment is that both it and the 1959 HIV-1 fragment are the results of the administering in Leopoldville and elsewhere in the Belgian Congo from 1957 onwards of different batches of an experimental live vaccine. This vaccine, an oral polio vaccine (OPV) called CHAT, was (as I have previously demonstrated) prepared locally in the Congo in chimpanzee cells, which cells were themselves almost certainly contaminated with SIVcpz (chimpanzee SIV, the immediate primate ancestor of HIV-1).

Part 1 of this essay gives a brief background to Worobey's latest paper.

In Part 2 I provide some analysis of the paper, and attempt to demonstrate where Dr Worobey has gone wrong.

In Part 3 I shall provide a much simpler explanation for the existence of this new HIV-1 sequence from 1960.

In Part 4 I shall provide some historical background to Dr Worobey's involvement in this debate.

And in Part 5 I shall provide more information about the large organised cover-up that has taken, and is taking place on this issue.

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Michael Worobey’s possession of 1950s tissue samples from Stanleyville (Kisangani) PDF Print E-mail
by Edward Hooper   
Wednesday, 19 March 2008

Michael Worobey’s possession of 1950s tissue samples from Stanleyville (Kisangani).

Michael Worobey’s first active participation in the origins-of-AIDS debate is believed to have occurred in late 1999, when Professor Bill Hamilton (a highly-respected evolutionary biologist, then rated by many as the “star” of the Royal Society) was seeking someone to accompany him on his second trip to the Democratic Republic of Congo (DRC) to test the SIV of wild chimpanzees.

Some background. Since I first met him in 1993, Bill Hamilton had been my mentor, and he wrote a powerful and highly supportive foreword to “The River”. In July 1999, after the book was completed but before it was published, Bill and I spent just over a week in the DRC, but we had some quite serious disagreements during the trip, which focussed on whether I was there mainly to help him with the collection of samples from local chimpanzees, or was also there to conduct my own historical research into Lindi Camp and the Laboratoire Medical de Stanleyville. We had obtained visas from the rebel government based in Kisangani (formerly Stanleyville) that were good for six further months, and Bill in particular wanted to return there to do more research. Since he and I were, by late 1999, still going through a cooling-off period (and since I was busy dealing with the response to The River, published in September 1999), Bill looked around for a companion in his own Department of Zoology at Oxford University, and came across a young Rhodes Scholar, Michael Worobey, who suggested that they also bring along a Canadian friend of his, Jeff Joy, who had practical skills and experience of living in the wilds.

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